Olanzapine-induced hepatopathy in albino rats: A newer model for screening putative hepatoprotective agents, namely silymarin
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چکیده
منابع مشابه
Screening of hepatoprotective effect of a herbal mixture against CCl4 induced hepatotoxicity in Swiss albino mice.
The hepatoprotective potential of a herbal mixture was evaluated against CCl4 induced liver injury in Swiss albino mice. Liv 52, a commercially available polyherbal hepatoprotective drug was evaluated for comparison. The potential toxicity of the above herbal hepatoprotective agents was also compared. It was observed that there was a reduction in the enzyme biomarkers (Aspartate and Alanine Tra...
متن کاملHepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats
This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM. Twelve hours after APAP administration, plasmatic levels of liver function ma...
متن کاملEffect of Silymarin against Deltamethrin - Induced Histological and Biochemical Changes in Liver of Albino Rats
Treating male albino rats with the pyrethroid insecticide, deltamethrin induced various histological changes in the liver. These changes included congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolization of the hepatocytes and fatty infiltration. Deltamethrin also caused significant elevation in serum ALT and AST enzymes after 2 and 3 weeks of treatment. . Silymarin, an ex...
متن کاملA Review on Hepatoprotective Activity of Silymarin
Silymarin is obtained from the seeds of Silybum marianum (milk thistle), an edible plant that has been used medicinally from ancient times for the treatment of various liver disorders. It is widely prescribed by herbalists and has almost no known side effects. The plant is native to the Mediterranean and grows throughout Europe, North America, India, China, South America, Africa and Australia. ...
متن کاملProtective effect of silymarin on metiram fungicide-induced hepatotoxicity in albino rats
Metiram is a member of the ethylene bis dithiocarbamate used to prevent crop damage in field crops and fruits. Si lymarin, an extract from Silybum marianum and showed many medicinal uses. The present work studied the effect of metiram on the liver of albino rats and the possible protective role of silymarin. Treating animals with metiram induced many histological changes in the liver incl uding...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2010
ISSN: 0253-7613
DOI: 10.4103/0253-7613.71924